Genetic factors in systemic sclerosis

درگیری پارانشیم ریه در بیماران سیستمیک اسکلروزیس در بیمارستان نور و الزهرای اصفهان

    Background & Aim:Systemic sclerosis is a multisystem autoimmune disorder with multiple organ involvements characterized by inflammation and fibrosis involving the skin as well as internal organs.  Pulmonary involvement consists of interstitial fibrosis and pulmonary vascular disease has an important effect on the course and survival of these patients. In this study, we investigated the prev...

XWH - 07 - 1 - 0277 TITLE : The Integrative Studies of Genetic and Environmental Factors in Systemic Sclerosis

Association of Pemphigus Vulgaris and Tuberous Sclerosis: A case report

Pemphigus vulgaris is a blistering autoimmune disease with suprabasal cleft formation, which is the most common autoimmune blistering disease in eastern countries, such as Middle East. Predisposition to pemphigus is linked to genetic factors. Tuberous sclerosis is also a genetic disorder of hamartoma formation in many organs, particularly the skin, brain, eye, kidney and heart. We report ...

High frequency skin ultrasonography in systemic sclerosis

Background: Systemic sclerosis is an autoimmune connective tissue disorder which is characterised by cutaneous and internal organ fibrosis. Raynaud’s phenomenon is the earliest feature and may precede the onset of the disease by months to years. The heart, lungs, gastrointestinal tract, kidneys and other organs may be involved. Our aim was to evaluate skin thickness and echogenicity in systemic...

Genetic Susceptibility to Interstitial Lung Disease Associated with Systemic Sclerosis

Systemic sclerosis (SSc) is a connective tissue disease that is characterized by tissue fibrosis, microvasculopathy, and autoimmunity. Interstitial lung disease (ILD) is a common complication of SSc and is one of the frequent causes of mortality in SSc. Although the exact etiology of SSc remains unknown, clinical and experimental investigations have suggested that genetic and environmental fact...

Transforming growth factor-beta in systemic sclerosis (scleroderma).

Deregulated transforming growth factor-beta (TGF-beta) activity and responses play prominent roles in the pathogenesis of systemic sclerosis (SSc), a chronic and progressive connective tissue disease characterized by fibrosis of the skin and internal organs. Systemic sclerosis has highly heterogeneous clinical manifestations, and patients can be classified into multiple subgroups on the basis o...